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Protox a Botox alternative
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ProTox 10 (Gel)
Protox 10 A new age in discovery
One of the first products to give a Legitimate alternative to BOTOX
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• Protox reduces the depth of wrinkles
• Protox prevents aging of the skin
• Ends the life of Botox injections
• Protox is applied as a gel
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Protox 10 introductory price £44.99
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Protox 20 extra strength introductory price £59.95
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Finally! A new age in discovery has created a formula so effective at diminishing wrinkles and creating a more youthful 'you', its one of the first cosmetic products to give you a legitimate alternative to
BOTOX.
Protox reduces the depth of the wrinkles around the eyes caused by the contraction of the muscles of facial expression.
Protox prevents aging of the skin induced by repeated facial movements mediated by excessive catecholamines release.
Protox extends the life of Botox injections reducing the number of procedures and saving you money.
Protox is applied as a gel, that moisturises and hydrates
Visible Results
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Using a device similar to those found in opticians to keep your head still and in one place, we photographed several test subjects with moderate wrinkles both prior to using Protox and after 30 days of applying Protox gel twice daily in 3 affected areas: a) the forehead furrows; b) the eye 'crow feet' and c) the smile creases.
Only Protox ( Botox alternative ) contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin. Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.
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Three markers were used to allow easy comparison between images. Notice how wrinkles denoted by the Arrows Blue and Red have become much less visible. Arrow Green has also shown pronounced visible benefit. Constant muscle movements in this area of the skin lead to frequent skin creasing which ends in wrinkles and fine lines. Protox can halt this.
Check out these Protox performance graphs
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You can find more detail on Catecholamine release and how this affects muscle tone and wrinkle definition.. Simply put, the more Catecholamine that is released by facial muscle nerves in response to Noradrenaline and/or Adrenaline stimulus, the more wrinkles that will appear and the deeper they will be.
The 'control' shows the standard amount of release under controlled conditions (ie. using no Botox substitute gel). It can easily be concluded from the above chart that Related Peptide Formulations are NOT as effective as Protox at reducing Catecholamine release.
The above chart shows in more detail how Protox compares with related peptide brands. No other Botox alternative can outperform
Protox. In some cases, Protox is 70% more effective and is 10% more effective than it's closest competitor.
Protox is the first and original Argireline formulation and still the only one available exclusively through skincare professional equipped retailers only.
Here's why you should only consider Protox when looking to augment your Botox injections or indeed to use instead of drastic measures:
Protox is formulated by government-regulated manufacturers according to the actual formula used in the Clinical Trials. This ensures you have the best chance of repeating the trial results on own skin.
Protox is manufactured using only the finest, pharmaceutical-grade processes, materials & ingredients.
Protox is presented in an airless system providing two crucial benefits; a) the system is hygenic and 'dirty' fingers do not enter the formula - a protein rich gel that will harbour and encourage bacteria growth) and b) preventing the air from reaching the formula will prevent the needless oxidation of ingredients meaning maximum potency right to the end.
Protox contains Sodium Hyaluronate and Seaweed extract that moisturise and hydrate the skin
LOADING PHASE: Gently massage into targeted facial lines and muscle points. Apply a thin coat around the eyes to clean, dry skin, twice daily Wait three minutes and then apply a good quality face moisturizer. Follow this procedure for three weeks.
MAINTENANCE PHASE: During this period apply Protox only once a day. Preferably in the morning. If working out or swimming in the AM, wait to apply after exercise. Use your best judgement and pick the time period which allows Protox to stay on your skin for the longest period of time.
Results can be seen starting in two to three weeks with maximum visible reduction of fine lines and wrinkles within 45-60 days. Most effective in orbital eye area and forehead.
BEYOND 90 DAYS: After 90 days apply Protox once or twice a week. Remember to continue to use your face moisturizer.
Choosing between Protox-10 and Protox-20 ProTox 10 (Gel)
Protox 10 A new age in discovery
One of the first products to give a Legitimate alternative to BOTOX
• Protox reduces the depth of wrinkles
• Protox prevents aging of the skin
• Ends the life of Botox injections
• Protox is applied as a gel
Protox has been shown to reduce the depth of wrinkles by upto 50% in 30 days.
Before you can understand how Protox works, you need to be familiar with how muscle contractions are stimulated. Remember, it is the attenuation or muting of muscle contraction in the facial muscle groups which allows wrinkles to 'flatten out' and become much less visible. The following is for educational purposes only.
When a nerve fires an 'action potential' which is a wave of cell wall depolarization, travels down the nerve fibre until it reaches the synaptic cleft (see left) which is the gap between the nerve and muscle tissue. The two tissues are not physically connected otherwise all 'flashes' of nerve activity would cause muscle contraction irrespective of the intensity or duration of nerve impulse.
An action potential must reach a certain level before it causes the 'synaptic vesicles' to fuse with the neurone cell wall (called exocytosis). This is rather like a soap bubble bursting and releasing it's contents into the surface that bumps into. In this case however, the contents of the vesicle is a neuro-transmitter called Acetylcholine (Ach). The ACh is therefore released into the synapic cleft space where the majority is taken back up by the nerve or broken down by an enzyme present in the synaptic cleft called Acetylcholisterase. Again if only a small amount of ACh reaches the muscle receptors, a contraction will not take place - so the small amount not re-absorbed or not broken down and reaching the muscle receptors will not cause a muscle contraction.
As the nerve action potential gets more and more intense, more ACh is released eventually leading to sufficient ACh landing on the muscle receptors, which then react by changing shape and letting in sodium ions. The inflood of positively charged Sodium ions sets up a new wave of depolarisation in the muscle fibre causing a contraction.
The diagram to the left shows the mechanism of action of Protox-like peptides. Note how two vesicles are releasing Ach into the synapse above but now with Protox added, only one vesicle fuses with the nerve fibre cell wall, thereby reducing the amount of Ach released or another way of looking at it - increasing the amount of stimulation required before muscle contractions occurs.
Advanced Explanation:
Protox contains a small hexapeptide that is designed to partially interfere with the SNARE (which is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25) This complex intervenes in the process of docking, fusing and exocytosis of these neuro-transmitter vesicles.
Protox is a mimic of the N-Terminal end of SNAP-25 which can therefore compete for a position in the SNARE complex, thereby modulating it's formation. If the complex is slightly destabilised, the vesicle is not able to release as much neuro-transmitter, thereby muting muscle contraction and helping to prevent the formation & visibility of wrinkles.
Importantly and unlike Botox (Botulinum Toxin A) Protox does not paralyse completely but acts in a very similar way. Both Botox and Protox only acts at the site of application.
PROTOX
DIRECTIONS
USE TWICE DAILY. ONCE IN MORNING AFTER CLEANSING BUT BEFORE ANYTHING ELSE, AND ONCE IN THE EVENING AFTER CLEANSING
INGREDIENTS
LIPOSOMES - are minute spherical capsules comprised of specific lipids, which mimic part of the skins natural structure. Liposomes are able to entrap a number of materials which they then protect. Because of their compatibility with the skins natural lipids the liposomes are able to penetrate deeper into the skin.
ARGIRELINE - ARGIRELINE® is a patented peptide which reduces the depth of wrinkles on the face caused by repeated facial movements, especially in the forehead and around the eyes.
HYALLURONIC ACID - Is a high-molecular naturally occuring material which forms a flexible film on the skin which has the ability to hold large quantities of water helping to effectively moisturise the skin, to help prevent cross-linking.
PML - Minute, multi-layered spheres which entrap active materials, protecting them until they are needed.
The PMLs help to transport the actives through the skin's surface to the lower layers of the skin, where the actives are then slowly released to implant the maximum benefit over a period of time.
PROTOX - PATENTED ARGIRELINE FORMULATION - CLINICALLY PROVEN TO REDUCE THE DEPTH OF WRINKLES BY UP TO 50% IN 30 DAYS.
- Protox reduces the depth of the wrinkles around the eyes caused by the contraction of the muscles of facial expression.
Protox prevents aging of the skin induced by repeated facial movements mediated by excessive catecholamines release.
Protox extends the life of Botox injections reducing the number of procedures and saving you money.
Protox is applied as a gel, that moisturises and hydrates -
Visible Results
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Aloe Vera
After 30 days
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Protox gel
After 30 days
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Protox 10 introductory price £44.99
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Protox 20 extra strength introductory price £59.95
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How does it work?
Protox works by relaxing the muscles in the face that otherwise are engaged in making expressions. These expressions crease the skin and cause lines and wrinkles. The permanent muscle tone present in many facial muscles make the creases look like deep furrows.
Protox DOES NOT PARALYSE the muscle, it has a gentle effect on the SNARE receptor causing a relaxing effect on muscles not total paralyse. Used on a regular basis Protox can therefore assist in eliminating the formation of wrinkles and soften and smooth out existing wrinkles.
Protox is a colourless fragrant -free gel and should be used twice daily as a treatment prior to using regular skin care products. Protox incorporates only pharmaceutical grade raw ingredients to ensure best possible results.
ORIGINAL FORMULA - PROTOX 10 SERUM - for less wrinkled & younger skin - as a maintenance or alternative to muscle paralysing injections
Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin. Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.
ADVANCED FORMULA - PROTOX 20 SERUM - for more mature, deeper wrinkled skin - as a maintenance or alternative to muscle paralysing injections.
Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin. Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.
Before you can understand how Protox works, you need to be familiar with how muscle contractions are stimulated. Remember, it is the attenuation or muting of muscle contraction in the facial muscle groups which allows wrinkles to 'flatten out' and become much less visible. The following is for educational purposes only.
 |
When a nerve fires an 'action potential' which is a wave of cell wall depolarization, travels down the nerve fibre until it reaches the synaptic cleft (see left) which is the gap between the nerve and muscle tissue. The two tissues are not physically connected otherwise all 'flashes' of nerve activity would cause muscle contraction irrespective of the intensity or duration of nerve impulse.
|
An action potential must reach a certain level before it causes the 'synaptic vesicles' to fuse with the neurone cell wall (called exocytosis). This is rather like a soap bubble bursting and releasing it's contents into the surface that bumps into. In this case however, the contents of the vesicle is a neuro-transmitter called Acetylcholine (Ach). The ACh is therefore released into the synapic cleft space where the majority is taken back up by the nerve or broken down by an enzyme present in the synaptic cleft called Acetylcholisterase. Again if only a small amount of ACh reaches the muscle receptors, a contraction will not take place - so the small amount not re-absorbed or not broken down and reaching the muscle receptors will not cause a muscle contraction.
As the nerve action potential gets more and more intense, more ACh is released eventually leading to sufficient ACh landing on the muscle receptors, which then react by changing shape and letting in sodium ions. The inflood of positively charged Sodium ions sets up a new wave of depolarisation in the muscle fibre causing a contraction.
|
 |
 |
The diagram to the left shows the mechanism of action of Protox-like peptides. Note how two vesicles are releasing Ach into the synapse above but now with Protox added, only one vesicle fuses with the nerve fibre cell wall, thereby reducing the amount of Ach released or another way of looking at it - increasing the amount of stimulation required before muscle contractions occurs.
|
Advanced Protox Explanation:
Protox contains a small hexapeptide that is designed to partially interfere with the SNARE (which is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25) This complex intervenes in the process of docking, fusing and exocytosis of these neuro-transmitter vesicles.
Protox is a mimic of the N-Terminal end of SNAP-25 which can therefore compete for a position in the SNARE complex, thereby modulating it's formation. If the complex is slightly destabilised, the vesicle is not able to release as much neuro-transmitter, thereby muting muscle contraction and helping to prevent the formation & visibility of wrinkles.
Importantly and unlike Botox (Botulinum Toxin A) Protox does not paralyse completely but acts in a very similar way. Both Botox and Protox only acts at the site of application.
PROTOX
DIRECTIONS
USE TWICE DAILY. ONCE IN MORNING AFTER CLEANSING BUT BEFORE ANYTHING ELSE, AND ONCE IN THE EVENING AFTER CLEANSING
INGREDIENTS
LIPOSOMES - are minute spherical capsules comprised of specific lipids, which mimic part of the skins natural structure. Liposomes are able to entrap a number of materials which they then protect. Because of their compatibility with the skins natural lipids the liposomes are able to penetrate deeper into the skin.
ARGIRELINE - ARGIRELINE® is a patented peptide which reduces the depth of wrinkles on the face caused by repeated facial movements, especially in the forehead and around the eyes.
HYALLURONIC ACID - Is a high-molecular naturally occuring material which forms a flexible film on the skin which has the ability to hold large quantities of water helping to effectively moisturise the skin, to help prevent cross-linking.
PML - Minute, multi-layered spheres which entrap active materials, protecting them until they are needed.
The PMLs help to transport the actives through the skin's surface to the lower layers of the skin, where the actives are then slowly released to implant the maximum benefit over a period of time.
PROTOX - PATENTED ARGIRELINE FORMULATION - CLINICALLY PROVEN TO REDUCE THE DEPTH OF WRINKLES BY UP TO 50% IN 30 DAYS.
How does it work?
Protox works by relaxing the muscles in the face that otherwise are engaged in making expressions. These expressions crease the skin and cause lines and wrinkles. The permanent muscle tone present in many facial muscles make the creases look like deep furrows.
Protox DOES NOT PARALYSE the muscle, it has a gentle effect on the SNARE receptor causing a relaxing effect on muscles not total paralyse. Used on a regular basis Protox can therefore assist in eliminating the formation of wrinkles and soften and smooth out existing wrinkles.
Protox is a colourless fragrant -free gel and should be used twice daily as a treatment prior to using regular skin care products. Protox incorporates only pharmaceutical grade raw ingredients to ensure best possible results.
ORIGINAL FORMULA - PROTOX 10 SERUM - for less wrinkled & younger skin - as a maintenance or alternative to muscle paralysing injections
Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin. Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.
...............................................................................................................................................................................................
ADVANCED FORMULA - PROTOX 20 SERUM - for more mature, deeper wrinkled skin - as a maintenance or alternative to muscle paralysing injections.
Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin. Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.
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